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192.168.6.56/handle/123456789/74993| Title: | Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products |
| Authors: | Noguchi, Taro |
| Keywords: | Chemistry |
| Issue Date: | 2018 |
| Publisher: | Springer Nature Singapore Pte Ltd. |
| Description: | Natural products and their derivatives are valuable resources for drug discovery. While most of chiral natural products are produced as single enantiomeric form in nature, mirror-image isomers of them are also potential resources for drug discovery because they have identical physicochemical properties and different biological properties. To screen the mirror-image library of chiral natural products, mirror-image screening strategy has been developed. In this strategy, the screening of chiral natural products using a chemically synthesized d-protein corresponds to that of mirror-image natural products using a native protein (l-protein) in a mirror. In an effort to identify anticancer agents from the mirror-image natural roducts, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. |
| URI: | http://10.6.20.12:80/handle/123456789/74993 |
| ISBN: | 978-981-10-6623-8 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2018_Book_DevelopmentOfChemistry-BasedSc.pdf | 4.59 MB | Adobe PDF | View/Open |
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