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192.168.6.56/handle/123456789/74993Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Noguchi, Taro | - |
| dc.date.accessioned | 2019-07-03T06:49:47Z | - |
| dc.date.available | 2019-07-03T06:49:47Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.isbn | 978-981-10-6623-8 | - |
| dc.identifier.uri | http://10.6.20.12:80/handle/123456789/74993 | - |
| dc.description | Natural products and their derivatives are valuable resources for drug discovery. While most of chiral natural products are produced as single enantiomeric form in nature, mirror-image isomers of them are also potential resources for drug discovery because they have identical physicochemical properties and different biological properties. To screen the mirror-image library of chiral natural products, mirror-image screening strategy has been developed. In this strategy, the screening of chiral natural products using a chemically synthesized d-protein corresponds to that of mirror-image natural products using a native protein (l-protein) in a mirror. In an effort to identify anticancer agents from the mirror-image natural roducts, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. | en |
| dc.language | en | en |
| dc.language.iso | en | en_US |
| dc.publisher | Springer Nature Singapore Pte Ltd. | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products | en_US |
| dc.type | Book | en_US |
| Appears in Collections: | Chemistry | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2018_Book_DevelopmentOfChemistry-BasedSc.pdf | 4.59 MB | Adobe PDF | View/Open |
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