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192.168.6.56/handle/123456789/74752| Title: | Amorphous Drugs |
| Authors: | Rams-Baron, Marzena Jachowicz, Renata Boldyreva, Elena Zhou, Deliang Jamroz, Witold Paluch, Marian |
| Keywords: | Drug |
| Issue Date: | 2016 |
| Publisher: | Springer International Publishing AG |
| Description: | Low aqueous solubility of active pharmaceutical ingredients (APIs) is one of the most important challenges facing drug development researchers today. With the development of computational chemistry and high throughput screening methods it is possible to obtain a large number of compounds with attractive therapeutic activity. However, at the same time the selection of novel active molecules with suitable biopharmaceutical properties (like solubility, intestinal permeability) becomes a great challenge and a bottleneck in drug development.Statistically, more than 40% of approved drugs and even 70–90% of those under investigations are poorly water-soluble and additional efforts are required to improve their water solubility. |
| URI: | http://10.6.20.12:80/handle/123456789/74752 |
| ISBN: | 978-3-319-72002-9 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2018_Book_AmorphousDrugs.pdf | 6.02 MB | Adobe PDF | View/Open |
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