Title:	Miniature Fluidic Devices for Rapid Biological Detection
Authors:	Escobedo, Carlos Brolo, Alexandre G. Oh, Sang-Hyun
Keywords:	Chemistry
Issue Date:	2018
Publisher:	Springer International Publishing AG
Description:	Rapid and sensitive detection of biomolecules and biological particles is vital to gaining insight into the fundamental life processes they enable, as well as discovering rare species linked to the pathogenesis of various disease states. While advances in nanotechnology have helped enable a new generation of miniaturized biosensors, this goal has proven difficult due to fundamental limitations of molecular capture and detection. For surface-based biosensors, detection of analyte is often limited by mass transport. Diffusion into the capture volume is typically a slow and low-yield process, with the problem being compounded for nanoscale sensors. Various schemes have been attempted to accelerate mass transport, such as electrokinetic pre-concentration of charged molecules, dielectrophoresis of neutral polarizable particles and molecules, or evaporation-driven concentration of sample droplets; while other schemes have focused on exploiting the nanometer-scale dimensions of nanostructured biosensors to reduce the transport time, forcing a sample solution through nanopores to shrink the diffusion distance.
URI:	http://10.6.20.12:80/handle/123456789/75394
ISBN:	978-3-319-64747-0
Appears in Collections:	Chemistry

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