Title:	Free-Radical Synthesis and Functionalization of Heterocycles
Authors:	Landais, Yannick
Keywords:	Heterocycles
Issue Date:	2018
Publisher:	Springer International Publishing AG
Description:	After being considered as curiosities at the beginning of the last century, radicals have emerged as particularly useful intermediates for organic transformations. Radical organic chemistry thus enjoyed a rapid growth in the 1980s, principally due to the availability of a large amount of kinetic and thermodynamic data allowing rationalized organic transformations. While for long time tin reagents remained essential to generate radical species, a ealth of “tin-free” methods have since appeared to overcome toxicity issues associated with the use of tin reagents. Recently UV-photochemical activation, also used for a long time to generate radical species, has undergone a renaissance with the rise of visible-light photoredox catalysis, certainly a hot topic in the field. Radical chemistry has thus rapidly become an indispensable tool, particularly in total synthesis, offering access to increasingly complex structures through cascade processes, most often avoiding the deleterious use of protecting groups. Complex heterocycles, including alkaloids or oxacycle natural products, are now ccessible through multiple radical cyclizations. Small promising heterocyclic “lead” compounds in drug discovery, particularly relevant for pharmaceutical and agrochemical industries, may now be prepared in a limited number of synthetic steps based on radical processes.
URI:	http://10.6.20.12:80/handle/123456789/75116
ISBN:	978-3-319-89521-5
Appears in Collections:	Chemistry

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