Title:	Antibacterials
Authors:	Mobashery, Shahriar Fisher, Jed F. Miller, Marvin J.
Keywords:	Chemistry
Issue Date:	2018
Publisher:	Springer International Publishing AG,
Description:	An essential – that is to say, life-saving – component of modern medicine is the reliable ability to suppress bacterial infection. The chemical entities entrusted with this responsibility correspond to exceeding structural diversity, mostly of natural product origin but increasingly as well of synthetic origin. They occupy a chemical space that is distinct in key respects as compared to the entities used in other therapeutic areas of medicinal chemistry. This distinction when combined with the perpetual increase in bacterial resistance mechanisms, the seeming sparseness of valid antibacterial targets, and the belief that antibacterial discovery offers a poor return-on-investment support a widespread concern as to the future reliability of antibacterial chemotherapy. While the assertion that the antibiotic apocalypse has yet to arrive is certainly correct and while considerable reasons for optimism exist, we must be mindful both that the harbingers of possible apocalypse will arrive first elsewhere (in the third world) and that successful drug discovery and development is emphatically noninstantaneous . The fourteen chapters of these two volumes on antibacterial drug discovery capture this urgency, and add to its dimension the challenge, perspicacity, and ingenuity of contemporary antibacterial discovery. The compounds represented within these chapters include the antibacterials of Nature (the antibiotics) – both as starting material and as inspiration – and de novo structures. The chapters emphasize antibacterial target selection, emerging concepts for antibacterial discovery and structure-activity refinement, and antibacterial clinical development and utility.
URI:	http://10.6.20.12:80/handle/123456789/74762
ISBN:	978-3-319-68097-2
Appears in Collections:	Chemistry

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