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192.168.6.56/handle/123456789/74640| Title: | Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases |
| Authors: | Jenner, Matthew |
| Keywords: | Biochemical Studies |
| Issue Date: | 2016 |
| Publisher: | Springer International Publishing Switzerland |
| Description: | Polyketides form a group of diverse and structurally complex bioactive natural products. Their biosynthesis is directed by multi-domain polyketide megasynthases (PKSs), which extend the acyl chain by a series of condensation and optional reduction steps. Phylogenetic work has shown that, in a particular group of type I systems known as trans-AT PKSs, the ketosynthase (KS) domains potentially harbour specificity towards the nature of the first four carbons of the intermediate substrate (e.g. beta-hydroxy, enoyl, methyl-branched). These results suggest a close link between KS evolution and substrate specificity. |
| URI: | http://10.6.20.12:80/handle/123456789/74640 |
| ISBN: | 978-3-319-32723-5 |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2016_Book_UsingMassSpectrometryForBioche.pdf | 14.29 MB | Adobe PDF | View/Open |
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