Title:	Diabetes and Aging-related Complications
Authors:	Sho-ichi Yamagishi
Keywords:	Diabetes
Issue Date:	2018
Publisher:	Springer
Description:	According to the recent report of Diabetes Atlas in 2015, diabetes affects 415 million people worldwide, that is, one in every 11 adults is estimated to have diabetes, and half of them are undiagnosed. Further, it is expected that the number of diabetic patients will increase to 642 million by 2040. Diabetes and its associated metabolic derangements are one of the most important risk factors for aging-related and lifethreatening disorders, such as atherosclerotic cardiovascular disease, chronic kidney disease, cancer, Alzheimer’s disease, and osteoporosis. Indeed, atherosclerotic cardiovascular disease accounts for about 60% of death in diabetic patients, and microvascular complications are leading causes of end-stage renal failure, acquired blindness, and foot amputations. In addition, hazard ratios of death from any cause, non-cardiovascular disease, and several cancers in diabetic patients are 1.8, 1.7, and 1.25, respectively, compared with nondiabetic individuals. Moreover, Alzheimer’s disease and osteoporotic bone fractures are highly prevalent in diabetes, and average life span and healthy life expectancy of diabetic patients are about 10–15 years shorter than those of nondiabetic subjects. These observations suggest that diabetes and its numerous complications are a global health burden and that early detection and treatment of various diabetes-related complications are urgently needed for slowing the aging process and achieving a successful life in diabetic patients. This book entitled Diabetes and Aging-Related Complications deals with why and how aging process is accelerated under diabetes, providing valuable and comprehensive information for management of various types of diabetes- and aging-related disorders. I organized a symposium on diabetes and aging in the 58th Annual Meeting of Japan Geriatrics Society in 2016. I selected the contributors of chapters mainly from scientists who presented their updated data in the symposium. I think that the book helps most of the researchers and clinicians in the field of diabetes and its related complications acquire more updated knowledge about a diverse range of topics. Recently, there is accumulating evidence that cumulative hyperglycemic exposure has contributed to the development and progression of diabetes- and agingrelated disorders. In the Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications (DCCT-EDIC) trials, former intensive therapy has been shown to be associated with the reduced risk of all-cause mortality over 27 years’ mean follow-up. The phenomenon is called as metabolic memory, thus suggesting that past hyperglycemic exposure may persistently cause chronic damage in numerous organs and tissues of diabetes that are not easily reversed, even by subsequent, relatively good glycemic control. In other words, the observations suggest that beneficial influence of early glycemic control on the risk of vascular complications and death is sustained in patients with diabetes. The readers of this book will also get information on underlying molecular mechanisms of the metabolic memory in diabetes.
URI:	http://10.6.20.12:80/handle/123456789/55233
ISBN:	978-981-10-4376-5
Appears in Collections:	Population Studies

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