Title:	Aging and Heart Failure
Authors:	Bodh I. Jugdutt
Keywords:	Heart Failure
Issue Date:	2014
Publisher:	Springer
Description:	The concept for this book on aging and heart failure (HF) was born in the 1980s with the publication of the book entitled The Aging Heart: Its Function and Responses to Stress , edited by Dr. Myron L. Weisfeldt, MD. It was later fueled along in the early 1990s by the monograph entitled Inclusion of Elderly Individuals in Clinical Trials: Cardiovascular Disease and Cardiovascular Therapy as a Model by Dr. Nanette K. Wenger, MD. Concurrently, observations in population studies and large randomized clinical trials (RCTs) suggesting that the elderly patient after myocardial infarction was at higher risk for cardiovascular (CV) complications and adverse left ventricular remodeling leading to HF added fuel to the burning fi re. The concept of cardiac remodeling as a mechanism of heart disease leading to HF has evolved since the mid-1970s following extensive bench-tobedside and bedside-to-bench research studies. Since the mid-1980s, the initial emphasis on HF related to pressure and volume overload led to theories on adaptive and maladaptive structural and functional remodeling after insults such as myocardial infarction (MI) and hypertension (HTN) and later expanded to pure and mixed pressure/volume overload states and a wide range of cardiomyopathies. The concept of adverse left ventricular remodeling during acute and subacute phases of MI established that adverse cardiac remodeling is a major mechanism for progressive left ventricular enlargement, deterioration of ventricular function, increased suffering, and deaths from chronic HF. Concurrently, over the last four decades, expanding knowledge about the biology of aging and the effects of aging on the response to insults by prevalent CV diseases such as MI and HTN has identifi ed several potential molecular pathways and targets that may lead to drug discovery and development and improved therapies for the ravages of these diseases in the elderly patient. A major payoff of the research studies has been the appreciation that lifelong exposure to CV risk factors and cardiotoxic agents from childhood through adulthood and old age fuels the march to HF. This has clearly opened up a new area of research into the biology of CV aging and its impact on cardiac remodeling throughout life.
URI:	http://10.6.20.12:80/handle/123456789/52600
ISBN:	978-1-4939-0268-2
Appears in Collections:	Population Studies

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