Title:	Accounting for immunoprecipitationefficiencies in the statistical analysis ofChIP-seq data
Authors:	Yanchun Bao, Veronica Vinciotti, Ernst Wit and Peter AC ’t Hoen
Keywords:	Accounting for immunoprecipitation
Issue Date:	2013
Description:	ImmunoPrecipitation (IP) efficiencies may vary largely between different antibodies and between repeated experiments with the same antibody. These differences have a large impact on the quality of ChIP-seq data: a more efficient experiment will necessarily lead to a higher signal to background ratio, and therefore to an apparent larger number of enriched regions, compared to a less efficient experiment. In this paper, we show how IP efficiencies can be explicitly accounted for in the joint statistical modelling of ChIP-seq data.
URI:	http://196.189.45.87:8080/handle/123456789/105447
Appears in Collections:	Accounting and Finance

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.